Parimal Das (Ph.D at BHU in Zoology)

Assosiate Professer since June 2008

Specialization: Molecular Genetics and Cytogenetics: Human Molecular Genetics, Cancer Genomics and Proteomics

Present title and affiliation

Primary affiliation Associate Professor

Office address: Centre for Genetic Disorders

Faculty of Science, Banaras Hindu University

Varanasi 221005, Uttar Pradesh

Contact No. 9307025080 (Mobile)

Email parimal@bhu.ac.in

hellow_parimal@yahoo.com

Research Interests:

(1) Mapping, identification and characterization of human disease genes

(2) Identification and characterization of critical gene/s and molecules for developing Cancer therapeutics.

(3) Identification and characterization of novel protein-protein interaction underlying human Neurodegenerative disorders with special reference to Parkinsonism.

Extramural Research funding:

Genetics of tooth development: Genes underlying tooth agenesis in human- Funded by Department of Biotechnology, Govt. of India. Period: 2010-2013

Intramural Funding:

Chromosomal and Molecular Genetic analysis of Facial Disorders - XI Plan Research Grant for new Faculty- From University Grants Commission, Govt. of India. (Period: 2010-2013)

Education:

DEGREE	UNIVERSITY	YEAR
B.Sc	University of North Bengal, India	1984
M.Sc.	Banaras Hindu University, India	1986
Ph.D.	Banaras Hindu University, India	1993

Professional Training/Appointments:

Post-doctoral fellowship Eukaryotic Gene Expression	National Institute of Immunology, N.Delhi, INDIA	May 1994 - April 1998
Post-doctoral fellowship (Human molecular Genetics)	Baylor College of Medicine Houston, Texas, USA	May 1998 - Feb 2003
Instructor (Neurology)	Baylor College of Medicine, Houston, Texas, USA	March 2003 April 2004
Instructor (Surgical Oncology)	M D Anderson Cancer Center Houston, Texas, USA	May 2004 Dec 2006
Instructor (Neurology)	Baylor College of Medicine Houston, Texas, USA	Jan 2007- June 2008
Associate Professor	CGD, BHU, INDIA	June 2008 ccoConCContinuing

Scholarships / Fellowships/Academic awards:

1. Awarded National Merit Scholarship, Dept. of Education, Govt. of INDIA (1978-1983)

2. Awarded National Merit Scholarship, Dept. of Education, Govt. of INDIA (1983-1986)

3. Awarded National Merit Scholarship, Special Assistance Program of University Grants

Commission, Government of India (1984 -1986)

4. Junior Research Fellowship from Department of Science & Technology (DBT),

Govt. of India (1987-1991)

5. Senior research Fellowship from University Grants Commission (UGC),

Govt. of India (1991-1993)

6. Post doctoral research fellowship from DBT/NIH collaborative project (1994-1997)

7. Post doctoral fellowship (May, 1998 June, 2004) from NIH, USA

Selected Publications:-

(1) Lazar AJF, Das P, Tuvin D, Korchin B, Zhu Q, Jin Z, warneke CL, Zhang PS, Hernandez V, Lopez-Terrada D, Pisters PW, Pollock R E and Lev D (2007) Angiogenesis-promoting gene patterns in alveolar soft part sarcoma. Clin Cancer Research Dec 15; 13:7314-7321

(2) Das P, Kotlingham D, Korchin B, Lazar A and Lev D (2007) A high prevalence of p53 exon 4 mutations in soft tissue sarcoma Cancer 109: 2323-2333

(3) Tarpey P, Pemberton T, Stockton D, Das P, Ninis V, Edkins S, Futreal P A, Wooster R, Kamath S, Nayak R, Stratton M and Patel P I. (2007)

A novel Gln358Glu mutation in Ectodysplasisn A associated with X-linked dominant incisor hypodontia. American Journal of Medical Genetics 143A: 390-394

(4) Rosenberg NA, Mahajan S, Gonzales C, Nino-Rosales L, Ninis V, Das P, Hegde M, Molinari L, Zapata G, Weber J L, Belmont J W and Patel P I (2006) Low levels of genetic differentiation across Indian populations PLoS Genetics 2(12):e215, 2052- 2061

(5) Liu J, Zhan M, Hannay JAF, Das P, Bolshakov SV, Kotilingam D, Yu D, Lazar AF, Pollock RE and Lev D ( 2006) Wild type p53 inhibits Nuclear Factor kB- induced matrix metalloproteinase-9 promoter activation: implications for soft tissue sarcoma growth and metastasis. Molecular Cancer Research 4: 803-810

(6) Lucas R E, Vlangos C N, Das P, Patel P I and Elsea SH (2001) Genomic organization of the ~1.5 Mb Smith-Magenis syndrome critical interval:

Transcription map, genomic contig, and candidate gene analysis European Journal of Human Genetics, 9:892-902 Times cited: 9 Ref: ISI Web of SCIENCE Citation Index

(7) Goldenberg M, Das P, Messersmith M, Stockton D W, Patel P I and DSouza R N (2000) Clinical, radiographic and genetic evaluation of a novel form of autosomal dominant oligodontia Journal of Dental Research, 79:1469-1475 Times cited: 15 Ref: ISI Web of SCIENCE Citation Index

(8) Stockton D W*, Das P*, Goldenberg M, DSouza R N and Patel P I (2000) Mutation of PAX9 is associated with oligodontia Nature Genetics 24:18-19 * Equal contributor first author Times cited: 106 Ref: ISI Web of SCIENCE Citation Index

(9) Shi Y P, Das P, Holloway B, Udhayakumar V, Tongren J E, Candal F, Biswas S, Ahmed R, Hasnain S E and Lal A A (2000) Development, expression, and murine testing of a multistage Plasmodium falciparum malaria vaccine candidate Vaccine, 18:2902-2914 Times cited: 11 Ref: ISI Web of SCIENCE Citation Index

Publications:

Papers published: (22)

(2) Das P, Kotlingham D, Korchin B, Lazar A and Lev D (2007) A high prevalence of p53 exon 4 mutations in soft tissue sarcoma Cancer 109: 2323-2333

(3) Tarpey P, Pemberton T, Stockton D, Das P, Ninis V, Edkins S, Futreal P A, Wooster R, Kamath S, Nayak R, Stratton M and Patel P I. (2007) A novel Gln358Glu mutation in Ectodysplasisn A associated with X-linked dominant incisor hypodontia. American Journal of Medical Genetics 143A: 390-394

(4) Rosenberg NA, Mahajan S, Gonzales C, Nino-Rosales L, Ninis V, Das P , Hegde M, Molinari L, Zapata G, Weber J L, Belmont J W and Patel P I (2006) Low levels of genetic differentiation across Indian populations PLoS Genetics 2(12):e215, 2052- 2061

(6) Zhang L, Hannay J A F, Liu J, Das P, Zhan M, Nguyen T, Hicklin D J, Yu D, Pollock R E and Lev D (2006) Vascular endothelial growth factor overexpression by soft tissue sarcoma cells: implications for tumor growth, metastatis, and chemoresistance. Cancer Research 66: 8770-8778

(7) Pemberton T J, Das P and Patel P I (2005) Hypodontia: genetics and future perspectives. Braz J Oral Sci. 4:695-706

(8) Das P,Hai M, Elcock C, Leal S M, Brown D T, Brook A H and Patel P I (2003) Novel missense mutation and a 288-bp exonic insertion in PAX9 in families with autosomal dominant hypodontia American Journal of Medical Genetics, 118A: 35-42 Times cited:19 Ref: ISI Web of SCIENCE Citation Index

(9) Das P, Stockton D W, Bauer C, Shaffer L G, DSouza R N, Wright J T and Patel P I (2002) Haploinsufficiency of PAX9 is associated with autosomal dominant hypodontia Human Genetics, 110:371-376 Times cited: 30 Ref: ISI Web of SCIENCE Citation Index

(10) Lucas R E, Vlangos C N, Das P, "Times New Roman";language:PT-BR;mso-ansi-language:PT-BR'>Patel P I and Elsea SH (2001) Genomic organization of the ~1.5 Mb Smith-Magenis syndrome critical interval: Transcription map, genomic contig, and candidate gene analysis European Journal of Human Genetics, 9:892-902 Times cited: 9 Ref: ISI Web of SCIENCE Citation Index

(11) Goldenberg M, Das P, Messersmith M, Stockton D W, Patel P I and DSouza R N (2000) Clinical, radiographic and genetic evaluation of a novel form of autosomal dominant oligodontia Journal of Dental Research, 79:1469-1475 Times cited: 15 Ref: ISI Web of SCIENCE Citation Index

(12) Stockton D W *, Das P*, Goldenberg M, DSouza R N and Patel P I (2000) Mutation of PAX9 is associated with oligodontia Nature Genetics 24:18-19 * Equal contributor first author

Times cited: 106 Ref: ISI Web of SCIENCE Citation Index

(13) Vlangos C N, Das P, Patel P I and Elsea S H (2000)

Assignment of developmentally regulated GTP-binding protein (DRG2) to human chromosome band 17p11.2 with somatic cell hybrids and localization to the Smith-Magenis syndrome critical interval Cytogenetics and Cell Genetics, 88:283-285 Times cited: 2 Ref: ISI Web of SCIENCE Citation Index

(14) Shi Y P, Das P, Holloway B, Udhayakumar V, Tongren J E, Candal F, Biswas S, Ahmed R, Hasnain S E and Lal A A (2000) Development, expression, and murine testing of a multistage Plasmodium falciparum malaria vaccine candidate Vaccine, 18:2902-2914 Times cited: 11 Ref: ISI Web of SCIENCE Citation Index

(15) Elsea S H, Mykytyn K, Ferrell K, Coulter K L, Das P , Dubiel W, Patel P I and Metherall J E (1999) Hemizygosity for the COP9 Signalosome Subunit Gene, SGN3, in the Smith-Magenis Syndrome American Journal of Medical Genetics, 87:342-348 Times cited: 12 Ref: ISI Web of SCIENCE Citation Index

(16) Krishnamurthy S, Chatterjee U, Gupta V, Prasad R, Das P, Panwar S, Hasnain S E ` and Prasad R (1998) Deletion of transmembrane domain (TM) 12 of CDR1, a multidrug transporter from Candida albicans,leads to altered drug specificity:Expression of a yeast multidrug transporter in baculovirus expression system Yeast, 15 : pp 535 - 550 Times cited: 20 Ref: ISI Web of SCIENCE Citation Index

(17) Hasnain S E, Jain A, Habib S, Ghosh S, Chatterji U, Ramachandran A, Das P, Venkaiah B, Pandey S, Bufeng Liang, Ranjan A, Natarajan K and Anser Azim C (1997) Involvement of host factors in transcription from baculovirus late gene promoters - a review Gene, 190: pp 113 118 Times cited: 12 Ref: ISI Web of SCIENCE Citation Index

(18) Raina A, Sulaiman IM, Ehtesham NZ, Das P, Ali A, Dogra TD and Hasnain SE. (1996). Characterization of a human alphoid satellite DNA sequence and its potential use in assessing genetic diversity in Indian populations. Gene, 173: pp 247 - 250 Times cited: 5 Ref: ISI Web of SCIENCE Citation Index

(19) Habib S, Burma S, Chatterjee U, Das P, Jain A, Mukherjee B, Natarajan K, Ranjan A and Hasnain SE. (1996). Transcriptional regulation from the AcNPV polyhedrin gene promoter. "In Current Developments in Animal Virology (ed. Wagner & Jameel), Oxford-IBH Publishers, New Delhi, INDIA, pp 205 - 210 (20) Das P and Raman R(1994): Inactivation of mammalian X-chromosome during spermatogenesis: Temporal expression of genes in the laboratory mouse. Journal of Biosciences, 19: pp 513-528. Times cited: 4 Ref: ISI Web of SCIENCE Citation Index

(21) Raman R and Das P (1991): Mammalian Sex Chromosomes III. Activity of pseudoautosomal steroid sulfatase enzyme during spermatogenesis in Mus musculus. Somatic Cell and Molecular Genetics, 17: pp 429-433. Times cited: 5 Ref: ISI Web of SCIENCE Citation Index

(22) Jain A, Ranjan A, Chatterji U, Das P , Ghosh S, Habib S, Pandey S, Ramachandran A, Venkaiah B and Hasnain SE High level expression of heterologous genes in insect cells is not dependent on promoters alone Invertebrate cell culture: Novel directions and Biotechnology applications, (Editor, J. Mitsuhashi & K. Maramorosch) Academic Press

Professional Expertise:

Cell Biology Techniques:

Cell separation, Cellular autoradiography,

Molecular Biology Techniques:

Gel electrophoresis (Agarose, Acrylamide, Agarose-Acrylamide composite), Bacterial tran